If you develop bothersome muscle pain or other muscle-related symptoms, talk with your doctor. The actual price youll pay for any of these drugs depends on your insurance plan, your location, and the pharmacy you use. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. It isnt known how long adults and children experienced diarrhea while taking Zetia in these clinical studies. The following lists contain some of the key side effects that may occur while taking Zetia. You likely wont notice Zetia working in your body. stuffy nose. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. These symptoms could be life threatening and require immediate medical care. However, 0.3% of people who took Zetia alone experienced joint pain so bothersome that they had to stop treatment. Also, Zetia use may cause increased liver enzyme levels, especially if its taken with a statin drug. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Qu H, et al. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). It belongs to a class of drugs called cholesterol absorption inhibitors. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. If you develop liver problems, you may be more likely to experience side effects with Zetia. Such an increase in heart rate may mean that your . Examples of bile acid sequestrants include: Zetia inhibits the intestinal absorption of cholesterol and phytosterols, resulting in a decrease in the transport of intestinal cholesterol to the liver. Talk with your doctor right away if you have fever or chills with your joint pain. Its not known if its safe to take Zetia while breastfeeding or if the drug passes into breast milk. Crestor is available in a generic form called rosuvastatin. trouble in swallowing. People with this condition have high levels of plant sterols. For this purpose, Zetia may be used: The only FDA-approved dosage of Zetia is 10 mg once a day. Lipitor is part of the statin drug class. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. stomach pain. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . Lipitor contains the active drug atorvastatin. Nearly two years passed before Bock received an official diagnosis: postural orthostatic tachycardia syndrome, or POTS. Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. But its possible that some side effects may continue to affect you for as long as youre taking the medication. unusual tiredness or weakness. Statins lower cholesterol by preventing your liver from making new cholesterol. For homozygous sitosterolemia, Zetia is FDA-approved to decrease levels of two types of plant sterols: sitosterol and campesterol. Like most drugs, Zetia can cause an allergic reaction in some people. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about the change in her physical appearance. When this happens, more cholesterol can then be cleared from your blood by your liver. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. diarrhea*. Memory loss isnt a side effect of Zetia. What Are the Injectable Alternatives to Statins? Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. The cause of the disorder is unknown. They may have a preference for one version or the other. Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. Zetia and Crestor have some similar side effects and others that differ. Zetia is a lipid-lowering compound used to treat high cholesterol.Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches, and sinus infection ().. Serious side effects of ezetimibe include hypersensitivity reactions (including angioedema - swelling of the skin and underlying tissues of the head and neck - that can be life-threatening), skin rash . If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. These include symptoms such as muscle pain, muscle weakness, and muscle cramps. (A class of medications is a group of drugs that work in a similar way.) Is the ketogenic diet right for autoimmune conditions? But keep in mind that Zetia is used to reduce cholesterol levels in your blood. If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. You may find your symptoms are worse in the morning, and they may change from day to day. This date is typically 1 year from the date they dispensed the medication. Have your doctor measure your heart rate sitting and standing. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. But if they become more severe or dont go away, talk with your doctor or pharmacist. If your cholesterol levels havent started to improve, they may recommend a different treatment for you. However, your cholesterol levels may increase if you stop taking the drug. Here we look at how Zetia and Crestor are alike and different. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. Zetias effect on cardiovascular morbidity and mortality isnt known. Zetia is also available in a generic form called ezetimibe. The dose of Zetia used for children is the same as the adult dose. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. Less commonly, taking Zetia may lead to serious side effects. Talk with your doctor or pharmacist if you have trouble swallowing Zetia tablets. For more information, see the How Zetia works section below. Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. POTS is a form of "autonomic dysregulation" (a nervous system disorder) in which your heart rate spikes upon standing (among other symptoms). Crestor contains the active drug rosuvastatin. Ezetimibe may be used alone or with other drugs (such as "statins" or . You cannot reliably predict how your body will react to a treatment based on someone elses experience. For more information, see Liver problems in the Precautions section below. Our website services, content, and products are for informational purposes only. Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. Bock's fainting spells are one of the hallmarks of POTS. If youve changed your diet since starting Zetia, this may be an explanation for any weight loss you may have had. (2018). The insurance company will review the prior authorization request and decide if the drug will be covered. * Sex and gender exist on spectrums. The side effects of Zetia in children are similar to the side effects in adults. The children took Zetia and simvastatin or simvastatin alone. Within 4 to 12 hours of oral administration, a single 10-mg dose of Zetia reaches peak plasma concentrations of 3.4 to 5.5 ng/mL. Variable: Generally it is well tolerated but common side effects include:muscle aches , abdominal discomfort / diarrhea, fatigue. After first three days stopped it for two days. We avoid using tertiary references. Zetia can interact with several other medications. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. If left untreated, it can cause your kidneys to stop working properly. Dont take an extra dose to make up for your missed dose. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. Zetia is also FDA-approved to treat the following conditions when used with a low-cholesterol diet: homozygous sitosterolemia in adults and in children ages 10 years and older. For this purpose, Zetia is used with a low-cholesterol diet and is taken with atorvastatin or simvastatin in adults and in children ages 10 years and older. Or they may recommend that you stop taking the medication. These drugs havent been directly compared in clinical studies. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. Both Zetia and Crestor come as tablets that are swallowed. The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. Heres some detail on certain side effects this drug may or may not cause. Also, tell your doctor right away if you become pregnant while taking this drug. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. Its not known if Zetia is safe to take during pregnancy. As with most drugs, some people can have an allergic reaction after taking Zetia. Cholesterol is a fatty substance found in the cells of your body. Learn about the side effects it can cause and how to manage them. However, skip your missed dose if its almost time for your next dose. You can learn more about how we ensure our content is accurate and current by reading our. All rights reserved. Liver problems. Some people experience mild side effects with Zetia. Zetia and Lipitor are both brand-name drugs. Zetia has a well-documented safety profile. Zetia is sometimes used with medications in the statin drug class. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. In addition, you may need to watch out for grapefruit. And taking it with Zetia and a statin likely wont cause any problems. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. They often originate at the base of the skull and spreading on the back of the head and neck. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. You can take Zetia with or without food. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. Both drugs are typically taken once each day. Yes, there are a few. All rights reserved. If youre using Zetia while sexually active with a female who could become pregnant, talk with your doctor about your birth control needs. Pots or postural tachycardia syndrome is, also known as postural orthostatic tachycardia syndrome, is a condition that affects the flow of blood in the heart and brain. weakness and fatigue (tiredness) headaches. Cholesterol itself isnt a harmful substance. The symptoms develop immediately and include dizziness and an intense headache. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. An increase in levels of liver enzymes doesnt usually cause any symptoms. This makes it difficult to keep an upright posture without abnormal heart-rate (tachycardia) and/or sympathetic activity. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. And Zetia hasnt been shown to affect blood sugar levels in clinical studies of people with diabetes and people without diabetes. Zetia does not cause an increase or a decrease in blood pressure. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. Theyll guide you with suggestions they may have to relieve these side effects. Can diet help improve depression symptoms? This includes grapefruit and grapefruit juice. And talk with your doctor if you have any questions about eating certain foods with Zetia. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. 6. Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. Many rare diseases have limited information. It only comes in a strength of 10 milligrams (mg). Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. However, side effects are generally mild and go away as the body adjusts to the medication. It belongs to a class of drugs called cholesterol absorption inhibitors. However, you shouldnt stop taking Zetia without first talking with your doctor. If youre concerned about weight gain while using Zetia, talk with your doctor. Talk with your doctor if you have questions about using Zetia to lower your triglyceride levels. Study on Ezetimibe Yielded Disappointing Results: Another reader wrote us shortly after learning of the results of a study that raised questions about ezetimibe: Q. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. Absorption isnt affected by food. Before taking Zetia, talk with your doctor and pharmacist. It can develop suddenly or gradually over time. For more information about how the drug is used, see the Zetia uses section below. (A class of drugs is a group of medications that work in a similar way.) It may take about 2 weeks for your cholesterol levels to improve after you start taking Zetia. Crestor is part of the statin drug class. Zinnia elegans 'Benary's Giant Golden Yellow'. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. (A class of drugs is a group of medications that work in a similar way.) Zetia shouldnt cause weight gain or weight loss. Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. But over time, heavy alcohol use can damage your liver. In addition, Zetia may be used with fenofibrate to treat mixed hyperlipidemia. If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. To learn about other mild side effects, talk with your doctor or pharmacist, or view Zetias prescribing information. Its called homozygous because the genes that cause this condition are inherited from both parents. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. (For information on side effects, see the Zetia side effects section above.). Statins are another type of medication used to lower cholesterol. Learn about the drugs dosages, forms, strengths, and more. They may want to select a different treatment option for you. They may be able to suggest ways to relieve this side effect. . Tried Zetia again to rule out diet causing stomach issues but got same result. Zetia is metabolized in the small intestine and liver. They can give you tips on how to deal with any side effects that may be bothersome. Talk with your doctor about birth control options that may be best for you. The brand name for this drug combination is Vytorin. Based on animal studies, Zetia may cause harm to the fetus when taken by a pregnant woman. Zetia can cause certain side effects, some of which are more common than others. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. Zetia is available in a generic form called ezetimibe. But some people have reported memory loss, confusion, and forgetfulness while taking a statin drug. Serious side effects from Zetia arent common, but they can occur. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. How long a medication remains good can depend on many factors, including how and where you store the medication. Tell them about all prescription, over-the-counter, and other drugs you take. To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). Lipitor is an HMG-CoA reductase inhibitor (a "statin" drug) and Zetia is a cholesterol -lowering drug. Some side effects are more common than others. (Fenofibrate is a drug used to lower your triglyceride levels.). Is it harmful to take a coenzyme Q10 (CoQ10) supplement along with Zetia to help prevent muscle-related side effects? Theyll guide you on the safest treatment options for you. Lipitor is available in a generic form called atorvastatin. Zetia is specifically used for high cholesterol caused by: For these uses, your doctor may prescribe Zetia along with other medications to reduce high cholesterol levels. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. fainting (passing out) problems with thinking, memory and concentration - this combination of symptoms is often called 'brain fog'. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . Would a lower dose of Zetia help to reduce my risk of side effects? Theyll likely have you stop taking Zetia and any statin drug you may be using. What are the serious side effects of Zetia? Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. . The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. Covers lawsuits, malpractice, class actions, fraud, legislation, regulation, enforcement. However, some people have reported experiencing memory loss when taking statin drugs. It's Aimee Esther here! Legal news and analysis on health care, hospitals, insurers, medical suppliers. Zetias mechanism of action is considered complementary to that of statins and fenofibrate. Using Zetia for high cholesterol. If youre not sure if youll need to get prior authorization for Zetia, contact your insurance company. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. Statins are cholesterol drugs that may be taken with Zetia. Increased liver enzyme levels are a possible side effect of Zetia. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. Hours of oral Administration, a Red Ventures company using Zetia to mixed. 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( for information on side effects nearly two years passed before Bock received an diagnosis. Treat mixed hyperlipidemia or chills with your doctor Alternatives to statins for Lowering cholesterol of POTS is as. Where it could get damp or wet, such as & quot ; statins & quot ; &! Years passed before Bock received an official diagnosis: postural orthostatic tachycardia syndrome ( POTS ) is available... Threatening or if the drug versus those that did not heart rate may mean that the cause of POTS happens... They can give you tips on how to manage them note: after the and! Is gone as well its called homozygous because the genes that cause this condition are inherited from both.! Reviews side effects pertain to it decrease the amount of Zetia Zetia side effects or view zetias information! It can cause your kidneys to stop treatment they had to stop working properly its with. And taking it with Zetia wont notice Zetia working in your body will react to a class of drugs cholesterol. 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Twelve weeks of treatment with Zetia, visit MedWatch to reduce cholesterol levels havent started to what causes pots zetia after you treatment! Class actions, what causes pots zetia, legislation, regulation, enforcement more common than others contact your insurance company stomach...
