subject to the conditions set forth herein. The stock is trading at a forward P/E ratio of ~28, which is a near-record low valuation multiple for the company. Last significant activity was in Q4 2019 which saw a ~20% stake increase at prices between ~$14.50 and ~$76. By: /s/ Scott Lessing 14159 capital, l.p., relying adviser, bbi (baker brothers investments), baker/tisch capital, l.p., relying adviser, baker brothers life sciences capital, l.p . It is the funds second-largest holding, occupying 14.9% of its total portfolio. to see more advanced email alert options such as selecting any type of To ensure our website performs well for all users, the SEC monitors the frequency of requests for SEC.gov content to ensure automated searches do not impact the ability of others to access SEC.gov content. specifically enforced against each of the parties hereto in any court of competent jurisdiction. NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy of which are Baker Brothers Life Sciences Capital, L.P. is entitled to a performance allocation under the Issuer's organizational documents. There was a marginal increase this quarter. These cookies will be stored in your browser only with your consent. offering of its Common Stock under the Securities Act of 1933, as amended. Youre viewing 5 of 7 investments. Section2(c), during the period beginning at the closing of the IPO until such time as the. Recession Risk Determine whether Baker Brothers Life Sciences grew or shrank during the last recession. Broker-Dealer(s): Goldman, Sachs & Co., . Pharmaceutical, a company in which the Baker Brothers Entities have been investor s since March 2006. (b)Notwithstanding the provisions of Section2(a), the Investor shall not be entitled to designate any Apellis Pharma (APLS): The small 0.63% APLS stake saw a ~36% increase last quarter at prices between ~$41 and ~$65. Administrator(s): SS&C Fund Services (Cayman) Ltd, , Rank: 58 out of 30967 registered private funds, Rank: 428 out of 30967 registered private funds, Rank: 7711 out of 30967 registered private funds. ACADIA Pharmaceuticals (ACAD): The ~3% ACAD stake was established in the 2012-2013 timeframe at very low prices. investment firm, was founded by Julian & Felix Baker in 2000. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Its. Madrigal Pharmaceuticals (MDGL) and Mirati Therapeutics (MRTX): These two small (less than ~1.10% of the portfolio each) stakes were kept steady this quarter. The increase happened at ~$72 per share. This analysis is for one-year following each trade, and . other electronic means), each of which may be executed by less than all of the parties hereto, each of which shall be enforceable against the parties actually executing such counterparts, and all of which together shall constitute one instrument. Additionally, Baker Bros. dont intend to dilute their status as highly successful biotech investors, as they do not intend to ever allocate assets in other industries. Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. Mr. Goller serves as a Partner of Baker Brothers Investments, a fund management company focused on long-term investments in life-sciences companies. We reserve the right to block IP addresses that submit excessive requests. 212-339-5600. time, and particular provisions of this Agreement may be waived or modified, with and only with an agreement or consent in writing signed by the Company and the Investor. The parties hereto irrevocably submit, in any legal action or proceeding relating to PitchBook helps you see a funds investments based on target industry, year and deal typeso you can quickly understand its strategy at a glance. substantially the same time and in the same manner as provided to such directors; provided, however, that such Observer shall agree to hold in confidence all information so provided; and provided, further, that the Company The stock currently trades at ~$133. Agreement means that certain Series C Preferred Stock Purchase Agreement, dated January15, 2021, by and among the Company, the Investor and the other parties thereto. Mr. Goller holds a B.S. Its stake in Seattle Genetics is up $1 billion since news of. Baker Brothers controls ~16% of the business. Investors that are familiar with biotech companies are likely to find some hidden gems amongst their holdings. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. this Agreement, to the jurisdiction of the courts of the United States located in the State of Delaware or in any Delaware state court and consent that any such action or proceeding may be brought in such courts and waive any objection that they may (f)Notice. Note: Regulatory filings since the quarter ended show them owning ~33.8M shares of Incyte. The Baker brothers have built a truly special hedge fund. All rights reserved. THIS AMENDED AND RESTATED NOMINATING AGREEMENT (this Agreement), dated as of April22, 2021, by and among TScan The fund targets investments in pharmaceuticals and biotechnology, life science and oncology industry. Note: We do not offer technical support for developing or debugging scripted downloading processes. In this respect, the Company shall give the Observer copies of all notices, minutes, consents, and other materials that it provides to its directors at Except as otherwise provided herein, the provisions hereof shall inure to the There are 20 positions that are significantly large (more than 0.5% of the portfolio each) and they are the focus of this article. They had an IPO in November. individual as a nominee to the Board of Directors if a majority of the disinterested members of the Board of Directors reasonably and in good faith determines, after consultation with the Companys outside legal counsel and upon written advice Note: Baker Brothers controls ~8.5% of the business. Subject to Section3(n) below, the provisions of this Agreement shall apply to the full extent set forth herein with respect to any and all shares of capitalstock of the Company or any successor or assign of the Company While the fund has made great gains since, the recent plunge has definitely compressed its unrealized gains, as the position was held stable once again. attendance at such meeting is reasonably likely to adversely affect the attorney-client privilege between the Company and its counsel or (ii)access to such information or attendance at such meeting is reasonably likely to result in a conflict Additionally, the rights set forth in this Section2(c) may While the companys revenue growth has seemingly stagnated over the past couple of years, it appears that the companys development pipeline remains rather strong. in Molecular and Cell Biology from The Pennsylvania State University, and a Masters in both Biotechnology and Business Administration from the University of Pennsylvania. Unauthorized attempts to upload information and/or change information on any portion of this site are strictly prohibited and are subject to prosecution under the Computer Fraud and Abuse Act of 1986 and the National Information Infrastructure Protection Act of 1996 (see Title 18 U.S.C. See how we calculate 13F filing performance here, Baker Brothers Portfolio & 4 Largest Public-Equity Investments, 20 Highest Yielding Monthly Dividend Stocks. The bottom line has never been positive, however, with losses persisting even as sales are growing. We are EVERSANA. Please send any feedback, corrections, or questions to support@suredividend.com. Recent M&A winners include Pharmacyclics (acquired by AbbVie), Synageva (acquired by Alexion), Salix (acquired by Valeant), and Alexion (acquired by AstraZeneca). Shares plunged by a massive 45%, and they have yet to recover since then. Signature and Submission Please verify the information you have entered and review the Terms of Submission below before signing and clicking SUBMIT below to file this notice. This article is part of a series that provides an ongoing analysis of the changes made to Baker Brothers 13F stock portfolio on a quarterly basis. Julian has a business background from Harvard, while Felix has a Ph.D. in Immunology from Stanford. Mr. Goller began his career as an investment banker with Merrill Lynch and Co. from 1997 to 1999. Focused on cloning strategies by analyzing 13F reports of a curated set of around fifty super-investors and generating Absolute Returns thru exploiting inefficiency, volatility, and momentum. Contact Information Fund Manager Baker Brothers Investments Fund Category Shares started trading at ~$49 and currently goes for $13.27. {"search": "/search", "clicked": "/clicked", "portfolio_add": "/portfolio-add", "portfolio_remove": "/portfolio-remove", "portfolio_create": "/portfolio-create", "portfolio_activate": "/portfolio-activate", "portfolio_delete": "/portfolio-delete", "portfolio_rename": "/portfolio-rename", "portfolio_color": "/portfolio-color", "home_filter": "/home-filter", "htmlspeed": "/htmlspeed", "add_tag_firm": "/add-tag-firm", "add_tag_click": "/add-tag-click", "copy_aum": "/copy-aum", "stripe_checkout": "/stripe-checkout", "update_card": "/update-card"}, {"uid": 50008486, "pid": -1, "pid_a": [], "name": "", "email": "", "blacklist_f": false, "paywall_f": false, "paywall_n": 0, "random_n": 0}. While the company has continued to grow, the business seems incapable of meeting investors past expectations. Seagen is a biotechnology company that focuses on the development and commercialization of therapies for the treatment of cancer. Necessary cookies enable the website to function properly. The fund targets investments in pharmaceuticals and biotechnology, life science and oncology industry. All rights reserved. If you accept, we, along with our partners, will also use analytics, advertising and social media cookies and other trackers, whose the details of the purposes are accessible from the button Set Preferences. We give you the access and tools to invest like a Wall Street money manager at a Main Street price. (d)Successors and Assigns. San Francisco Bay Area, Silicon Valley), Operating Status of Organization e.g. Please. All remedies, either under this Agreement, or by law or otherwise afforded to any party, shall be cumulative and not alternative. This SEC practice is designed to limit excessive automated searches on SEC.gov and is not intended or expected to impact individuals browsing the SEC.gov website. Together, they have combined their individual expertise to generate superior returns by focusing solely on the biotech industry. of interest or (B)to protect trade secrets (unless covered by an enforceable confidentiality agreement, in a form reasonably acceptable to the Company), or a conflict of interest, of if the Investor or Observer is a competitor of the Company. enable the Investor to propose a replacement Investor Designee in accordance with the terms of this Agreement. Our clients include: large branded pharmaceutical companies established and emerging biotechnology companies international medical devices companies food and beverage companies The fund has grown rapidly over the years due to its extraordinary returns and currently boasts approximately $15.2 billion of assets under management (AUM). You can download an Excel spreadsheet with metrics that matter of Baker Brothers Advisors current 13F equity holdings below: Click here to instantly download your free spreadsheet of all Baker Brothers Advisors Stocks now, along with important investing metrics. This website uses cookies to improve your experience while you navigate through the website. You also have the option to opt-out of these cookies. Note: Regulatory filings since the quarter ended show them owning 4.7M shares (15.1% of business) of Entrada Therapeutics (TRDA). Companys Amended and Restated Certificate of Incorporation as in effect on the date hereof). The position was rebuilt between Q3 2014 to Q1 2015 at prices between ~$55 and ~$125. This Agreement, the Bylaws and Although there are ~120 positions in the 13F portfolio, the holdings are concentrated among a few large stakes. I have no business relationship with any company whose stock is mentioned in this article. Entrada is a pioneer in a new category of therapy called Endosomal Escape Vehicles - EEV. The life sciences sector is changing by the minute. Is this happening to you frequently? However, most of them comprise risky pre-revenue firms that should only be considered upon having a great understanding of their business model. inclusion in the Companys proxy materials for meetings of stockholders promptly after the Company requests such information from the Investor, and will cause the Investor Designee to submit on a timely basis to the Company a completed and Please disable your ad-blocker and refresh. It does not store any personal data. Get the full list, Massachusetts Institute of Technology Long-Term Disability Plan, Youre viewing 5 of 11 limited partners. Baker Brothers Life Sciences, L.P. is a hedge fund operated by Baker Brothers Investments and has approximately $13.9 billion in assets. Kymera Therapeutics (KYMR), Legend Biotech (LEGN), and Pacific Biosciences (PACB): These three very small (less than ~0.65% of the portfolio each) stakes were increased during the quarter. Sign-up The 2007-2008 timeframe saw the position increased from ~3.2M shares to ~11.1M shares at prices in the high single digits. Baker Bros Advisors was founded in 2000 and is based in New York City. IGM Biosciences (IGMS): The ~1% of the portfolio stake in IGMS goes back to funding rounds prior to the September 2019 IPO. the provisions of this Agreement shall be appropriately adjusted. (whether by merger, consolidation, sale of assets or otherwise) that may be issued in respect of, in exchange for, or in substitution for the shares of Common Stock, by combination, recapitalization, reclassification, merger, consolidation or Analytical cookies are used to understand how visitors interact with the website. They add up to ~73% of the portfolio. Form D contains basic information about the offering and the company. Investor and its Affiliates, collectively, no longer beneficially own the Required Shares, the Company shall invite a designee of the Investor (the Observer) to attend all in compliance with applicable laws, rules and regulations, subject to the requirements of fiduciary duties. But Chicago's lab space is . The position has remained almost steady since. BeiGene is an early commercial-stage biopharmaceutical firm working on developing and commercializing innovative molecularly-targeted and immune-oncology drugs for the treatment of cancer. Note: Baker Brothers controls ~10% of Madrigal Sciences. Baker Bros. Advisors LP 860 Washington Street, 3rdFloor New York, NY 10014 (212) 339-5690 (Name, address and telephone number of person authorized to receive notices and communications) January 12, 2023 (Date of event which requires filing of this statement) If the filing person has previously filed a statement on Schedule This website uses cookies to improve your experience. Positions that are between 0.10% and 0.50% of the portfolio are Achilles Therapeutics plc (ACHL), Adaptimmune Therapeutics plc (ADAP), ADC Therapeutics SA (ADCT), Aeglea BioTherapeutics (AGLE), Aerovate Therapeutics (AVTE), Aligos Therapeutics (ALGS), Alkermes plc (ALKS), Allakos (ALLK), Atreca (BCEL), BioAtla (BCAB), bluebird bio (BLUE), Cerus Corporation (CERS), Chinook Therapeutics (KDNY), DBV Technologies SA (DBVT), Forma Therapeutics (FMTX), Fulgent Genetics (FLGT), Global Blood Therapeutics (GBT), Horizon Therapeutics (HZNP), Immatics NV (IMTX), Immunocore Holdings plc (IMCR), Insmed Incorporated (INSM), Instil Bio (TIL), Kiniksa Pharmaceuticals (KNSA), Krystal Biotech (KRYS), Merus NV (MRUS), Neoleukin Therapeutics (NLTX), Neurocrine Biosciences (NBIX), Novavax (NVAX), Nurix Therapeutics (NRIX), Opthea Limited (OPT), Reata Pharmaceuticals (RETA), Rhythm Pharmaceuticals (RYTM), Talis Biomedical Corporation (TLIS), Travere Therapeutics (TVTX), Ultragenyx Pharmaceutical (RARE), Verastem (VSTM), Verve Therapeutics (VERV), and Zymeworks (ZYME). Sure Dividend compiles the following stock market databases and updates them monthly: Thanks for reading this article. I am not receiving compensation for it (other than from Seeking Alpha). Its flagship products include JAKAFI, which is a drug for the treatment of myelofibrosis and polycythemia, and Iclusig, a kinase inhibitor to treat chronic myeloid leukemia. Updated on November 23rd, 2022 by Nikolaos Sismanis. Biotechnology company that focuses on the biotech industry experience while you navigate through the website with. Julian & Felix Baker in 2000 and is based in new York City invest like a Wall Street money at. By focusing solely on the date hereof ) Genetics is up $ billion. C ), during the period beginning at the closing of the portfolio submitting a certain word or phrase a. Biotech industry than from Seeking Alpha ), which is a biotechnology company that focuses on date... 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