Isosorbide dinitrate or mononitrate can be used alone or in combination as either second-line or third-line therapy in patients previously treated with a -blocker. 1 0 obj fosphenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)nafcillin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)isosorbide mononitrate increases effects of methylergonovine by decreasing metabolism. Sublingual: 2.5-10 mg every 4-6 hours. Monitor Closely (1)efavirenz will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. It will remain primed for 6 weeks. Consider increasing CYP3A substrate dose if needed. isosorbide mononitrate increases effects of ergoloid mesylates by decreasing metabolism. Isosorbide mononitrate belongs to the group of medicines called nitrates. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. ACCF and AHA state that combined therapy with isosorbide dinitrate and hydralazine also can be useful in patients with current or prior symptomatic heart failure with reduced ejection fraction who cannot receive an ACE inhibitor or angiotensin II receptor antagonist [off-label] because of drug intolerance, hypotension, or renal insufficiency. Modify Therapy/Monitor Closely. Contraindicated. Serious - Use Alternative (1)isosorbide mononitrate increases effects of ergotamine by decreasing metabolism. N Eng J Med 1998;338:520-31 2. drip: 3-5 minutes. May repeat in 5 minutes if needed. Serious adverse reactions to the organic nitrates and nitrites are uncommon and their adverse effects mainly involve the CNS and cardiovascular system. Your dose may need to be gradually decreased.Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Last updated on Feb 7, 2022. Use Caution/Monitor. rucaparib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The dose can be increased to 10 mg twice daily after 2 to 3 days. 2 0 obj Abstract. Particularly small stature, initially: 5 mg ( of a 10-mg tablet) twice daily, for no longer than initial 2 days. Conventional measures in the management of angina pectoris are aimed at reducing the frequency, duration, and severity of attacks, and include coronary risk reduction (e.g., discontinuance of smoking, weight control, antilipemic strategies), rest, avoidance of precipitating circumstances (e.g., eating heavy meals, getting emotionally upset, performing strenuous exercise, exposure to cold air) and, if possible, treatment of the underlying cause. Ask your doctor before using any headache pain medication. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Doses used in clinical trials have ranged from 1/2 inch (1.3 cm; 7.5 mg) to 2 inches (5.1 cm; 30 mg), typically applied to 36 square inches (232 square centimeters) of truncal skin. Use Caution/Monitor. rifampin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. - Isosorbide Dinitrate - Isosorbide Mononitrate - Immediate release - Sustained release - 1 inch q6h - 0.4 mg/h - 15 mg tid - 10 mg bid - 30 mg/day REFERENCES 1. Isordil (isosorbide dinitrate) is a nitrate indicated for the prevention of angina due to coronary artery disease and congestive heart failure. Consult your pharmacist or local waste disposal company. Tape applicator in place. Either increases effects of the other by pharmacodynamic synergism. commonly, these are "non-preferred" brand drugs or specialty commonly, these are "non-preferred" brand drugs. Prophylactic management in situations likely to provoke angina attacks in patients who fail to respond to sublingual nitroglycerin: place 2.55 mg of isosorbide dinitrate under the tongue about 15 minutes prior to engaging in such activities. A larger area may be used. Minor/Significance Unknown. provider for the most current information. Caution in volume depletion or preexisting hypotension. isosorbide mononitrate, captopril. Monitor Closely (1)dabrafenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)fosphenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 4 0 obj Modify Therapy/Monitor Closely. Avoid extremities below the knee or elbow, skin Employ intermittent dosing of nitrates (e.g., use of a nitrate-free interval of 1012 hours daily) to minimize or prevent the development of tolerance to the hemodynamic and antianginal effects of the drugs. . Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. Available for Android and iOS devices. stream istradefylline will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. idelalisib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat.A very serious allergic reaction to this drug is rare. After . Either increases effects of the other by additive vasodilation. Contraindicated. This medication belongs to a class of drugs known as nitrates. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Modify Therapy/Monitor Closely. Allow powder to dissolve without swallowing. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. Do not use medications containing isosorbide dinitrate while using isosorbide mononitrate.This medication may interfere with certain laboratory tests (including cholesterol levels), possibly causing false test results. It is recommended that minoxidil be taken with a diuretic and beta blocker (see. Short periods (10-12 hours) of nitrate withdrawal help minimize tolerance. x\[o~`kYH]r M 0-:/n77nnN,v.V"mYf/2[7bf?x>}>\wG }Nx'XT^FVw_fo ~;Hfz^@mlgz]3GD6'lKi~6A-,Bw Lt"i'1Y}=7Og b-yb@Y=lY(v -l`'c#EqxXhb MANO{65j5H$~$2J-;oHDI~ IY~wr_x Subsequent studies discovered that a chemical reaction between . The drug information provided is intended for reference only and should not be used as a substitute for medical advice. Avoid or Use Alternate Drug. MEDICAL ALERT: Your condition can cause complications in a medical emergency. nitroglycerin rectal, isosorbide mononitrate. Warn all patients taking either selective PDE inhibitors or organic nitrates or nitrites of the potential consequences of taking the drugs within close proximity (e.g., within 24 hours of sildenafil; possibly more prolonged periods of risk with longer-acting PDE inhibitors) of taking a nitrate- or nitrite-containing preparation. Brand names: Dilatrate, Imdur, Ismo, Isordil, Monoket Drug class: Nitrates and Nitrites VA class: CV250 Chemical name: d-Glucitol-1,4:3,6-dianhydrodinitrate Molecular formula: C 6 H 8 N 2 O 8 C 6 H 9 NO 6 . Observe for possible additive hypotensive effects during concomitant use. Extended-release tablets: Approximately 7780%. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. Comment: Acetylcysteine may enhance vasodilatory effects of nitrates. Serious - Use Alternative (1)ivosidenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 1 - 2 sprays onto or under the tongue at the onset of pain. tetracaine, isosorbide mononitrate. stiripentol, isosorbide mononitrate. Modify Therapy/Monitor Closely. Comment: Monitor for signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered. commonly, these are generic drugs. Either increases toxicity of the other by Other (see comment). IMDUR Extended Release Tablets should not be chewed or crushed and should be swallowed together with a half-glassful of fluid. Each drug may cause hypotension. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Vasodilatory effect on arteriolar resistance is not as great as the action on the venous side; as a result of this combined action, both venous filling pressure (preload) and, to a lesser extent, arterial impedance (afterload) are reduced. Tecovirimat is a weak CYP3A4 inducer. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Reliable assay techniques for plasma nitroglycerin levels have only recently become available, and studies using these techniques to define the pharmacokinetics of nitroglycerin ointment have not been reported. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Use entire contents of foilpac to obtain full dose and discard immediately after use. Tell your doctor if you are pregnant or plan to become pregnant before using Imdur; it is unknown how it may affect a fetus. Side effects of Imdur and Ranexa that are similar include headache and dizziness. Monitor Closely (1)dichlorphenamide and isosorbide mononitrate both decrease serum potassium. imdur - UpToDate Adult Patient Graphics Showing results for Imdur (Isosorbide mononitrate) Search instead: Nitrates Nitrates in the management of chronic coronary syndrome sustained-release once-a-day preparation since it can be given once daily. Comes in 4.1g (90 sprays) and 8.5g (230 sprays) bottle. Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease. Drug Therapy: Nitrate therapy for stable angina pectoris. ;6YXZp2k>!'Z)IfFW`VG@Y!b /r980t ~pE phenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Isosorbide mononitrate conventional tablets, peak: 0.51 hour. Minor/Significance Unknown. Careful clinical or hemodynamic monitoring for possible hypotension or tachycardia if used in acute MI or heart failure. Isosorbide dinitrate is contraindicated in patients with shock or marked low blood pressure. HOW TO USE: Take this medication by mouth as directed by your doctor, usually twice a day. Isordil may also interact with blood pressure medications, dihydroergotamine or ergotamine, and beta-blockers. Imdur and Ranexa belong to different drug classes. Avoid or Use Alternate Drug. lenacapavir will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fedratinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. prescription products. In some controlled trials of other organic nitrate formulations, efficacy has declined with time. CAS number: 87-33-2. ivosidenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May increase dosage to 120 mg (as a single 120-mg tablet or as two 60-mg tablets) once daily after several days; 240-mg dosages rarely needed. Avoid or Use Alternate Drug. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Molecular formula: C6H8N2O8C6H9NO6 Modify Therapy/Monitor Closely. Isosorbide dinitrate: Metabolized extensively; about 1525 and 7585% of a dose is metabolized to isosorbide-2-mononitrate and isosorbide-5-mononitrate (referred to simply as isosorbide mononitrate), respectively; both metabolites are pharmacologically active, especially isosorbide mononitrate. Monitor Closely (1)isosorbide mononitrate, bupivacaine implant. Mechanism: additive vasodilation. Minor/Significance Unknown. To view formulary information first create a list of plans. drip: Immediate, Duration: Sublingual tablet: 30-60 minutes; Translingual spray: 30-60 minutes; Buccal tablet: 2 hours; Sustained release: 4-8 hours; Topical: 2-12 hours; Transdermal: 18-24 hours; I.V. [9]. Avoid or Use Alternate Drug. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Monitor Closely (1)rucaparib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. No specific dosage recommendations for hepatic impairment. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Do Not Copy, Distribute or otherwise Disseminate without express permission. Your doctor may increase your dose as needed. Start with lower doses and titrate slowly. Individual plans may vary RxList does not provide medical advice, diagnosis or treatment. Modify Therapy/Monitor Closely. Monitor Closely (1)tetracaine, isosorbide mononitrate. (See Tolerance and Dependence under Cautions.). To administer, empty the contents of a packet under the tongue, close mouth and breath normally. imdur to isordil imdur vs nitro patch. If not feasible, avoid use of abametapir. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Coadministration of nitrates or nitric oxide donors is contraindicated due to risk of hypotension. Symptoms of overdose may include: slow heartbeat, vision changes, severe nausea/vomiting, sweating, cold/clammy skin, bluish fingers/toes/lips. (See Selective Phosphodiesterase (PDE) Inhibitors under Cautions.). Readily (and almost completely) absorbed from the GI tract and oral mucosa, but considerable variations in the bioavailability (1090%) secondary to extensive first-pass metabolism in the liver. You are being redirected to Conventional tablets (e.g., Monoket): Tight, light-resistant containers at 1530C. Importance of warning all patients receiving organic nitrates or nitrites about the potential interaction between the drugs and selective PDE inhibitors, even if they currently are not receiving the drugs, since there is substantial potential for patients to receive the drugs from another clinician, from a friend, with little or no clinical intervention (e.g., via the Internet), or illicitly. Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. Monitor Closely (1)bosentan will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. affecting hepatic/intestinal enzyme CYP3A4 metabolism. ribociclib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Side effects of Imdur and Isordil that are similar include headache and dizziness. Contraindicated (1)isosorbide mononitrate, sildenafil. Daily dose free interval of at least 14 hours is advised to minimize tolerance. Free Consultation! Drug class: Nitrates and Nitrites apalutamide will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Less frequent administration of isosorbide dinitrate may reduce the development of tolerance to the drugs antianginal effects. Drug class: Antianginal agents. Sign Up Nitrate tolerance in angina therapy. Do not rub into the skin. Take the dose in the morning right after you wake up. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Either increases effects of the other by pharmacodynamic synergism. Most Both drugs lower blood pressure. We comply with the HONcode standard for trustworthy health information. MISSED DOSE: If you miss a dose, take it as soon as you remember. For maintenance therapy, 10 mg to 40 mg, two or three times daily, is recommended. lofexidine, isosorbide mononitrate. levoketoconazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Attempts to overcome nitrate tolerance by dose escalation, even to doses far in excess of those used acutely, have consistently failed. Known hypersensitivity to isosorbide or any ingredient in the respective formulation. endobj Maximum: 80 mg 3 times/day. This site complies with the HONcode standard for trust- worthy health information: verify here. Most Avoid or Use Alternate Drug. Contraindicated. After several days, the dosage may be increased to 120 mg (given as a single 120 mg tablet or as two 60 mg tablets) once daily. Headache, the most frequent adverse effect, may be severe (persistent or transient) and is perceived as a pulsating, throbbing sensation; frequent early in therapy, usually diminishes rapidly, and may disappear within several days to weeks of continuous therapy. Avoid or Use Alternate Drug. Imdur Dosage Generic name: isosorbide mononitrate 30mg Dosage form: tablet, extended release Drug class: Antianginal agents Medically reviewed by Drugs.com. acetazolamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088. Risk of increased SBP, angina pectoris. abametapir will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your doctor for more details. This information is not individual medical advice and does not substitute for the advice of your health care professional. Manufacturers state that selective phosphodiesterase (PDE) inhibitors (e.g., sildenafil, tadalafil, vardenafil) are contraindicated in patients receiving nitrates. As drug information can and will change at any time, RxList.com makes every effort to update its drug information. NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood pressure) should be done while you are taking this medication. Consider dose reduction of sensitive CYP3A4 substrates. Eccentric dosing with isosorbide-5-mononitrate in angina pectoris. cenobamate will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust dose of drugs that are CYP3A4 substrates as necessary. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).Isosorbide mononitrate is very similar to isosorbide dinitrate. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload. %PDF-1.4 Use Caution/Monitor. Only after nitrates had been absent from the body for several hours was their anti-anginal efficacy restored. Use Caution/Monitor. This document does not contain all possible drug interactions. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. isosorbide mononitrate, sildenafil. Organic nitrate that causes systemic venodilation, decreasing preload; enters vascular smooth muscle and is converted to nitric oxide, leading to activation of cyclic guanosine monophosphate and vasodilation, Relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, as well as myocardial oxygen demand; also improves coronary collateral circulation, lowering blood pressure, increasing heart rate, and causing occasional paradoxical bradycardia, Bioavailability: Immediate release, 93-100%; extended release, 77-80%, Onset (antianginal effects): Immediate release, 60 min; extended release, 60 min, Onset (hemodynamic effects): Immediate release, 10-30 min; extended release, 6 hr, Duration (antianginal effects): Immediate release, 5-7 hr; extended release, 8 hr, Duration (hemodynamic effects): Immediate release, 10-30 min; extended release, 6 hr, Peak plasma time: Immediate release, 30-60 min; extended release, 3-4.5 hr, Metabolites: Isosorbide, 5-isosorbide mononitrate glucuronide, sorbitol (inactive), Half-life: Parent drug, 6.2-6.6 hr; glucuronide metabolite, 6 hr; sorbitol metabolite, 9 hr. Use Caution/Monitor. Monitor Closely (1)ribociclib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Growing cells of Tetrahymena thermophila (T. t.) metabolized, after 72 h, 80% of isosorbide dinitrate (ISDN) to isosorbide 5-mononitrate (5-ISMN) and isosorbide 2-mononitrate (2-ISMN) in a ratio 5-ISMN/2-ISMN=2.6 as evaluated by HPLC. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site. Parker JO. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Monitor Closely (1)crofelemer increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The recommended starting dose of IMDUR Tablets is 30 mg (given as a single 30 mg tablet or as 1/2 of a 60 mg tablet) or 60 mg (given as a single tablet) once daily. Use Caution/Monitor. ACCF and AHA recommend initial dosage of 2030 mg 3 or 4 times daily; give concomitantly with hydralazine hydrochloride 2550 mg 3 or 4 times daily. The effect of food on the bioavailability of isosorbide dinitrate when administered in fixed combination with hydralazine hydrochloride is not known. Dose adjustments do not appear to be necessary in kidney disease. Isosorbide mononitrate IR | Monoket | ISMO, Nitroglycerin patch | Nitro-Dur | Minitran, Bidil (hydralazine + isosorbide dinitrate), Isosorbide mononitrate IR (Monoket, ISMO), Nitroglycerin patch (Nitro-Dur, Minitran), Phosphodiesterase type 5 inhibitors (Viagra, Cialis, sildenafil, etc. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Avoid or Use Alternate Drug. Initially, isosorbide dinitrate 20 mg and hydralazine hydrochloride 37.5 mg (1 tablet of BiDil) 3 times daily. To apply the ointment using one of the applicators, place the applicator on a flat surface, printed side down. Not known whether geriatric patients respond differently than younger patients. Do not break the 30 mg tablet. Medically reviewed by Drugs.com. Contact the applicable plan Supplied: Capsule, sustained release (Dilatrate-SR): 40 mg Tablet: 5 mg, 10 mg, 20 mg, 30 mg, 40mg Tablet, extended release (Isochron): 40 mg Sublingual tablet: 2.5 mg, 5 mg. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). Either increases effects of the other by pharmacodynamic synergism. Caution if used in nursing women. Use Caution/Monitor. Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. A local search option of this data can be found here. Minor/Significance Unknown. The two doses should be administered 7 hours apart in order to avoid tolerance (decreased effect after several doses). May decrease dosage to as little as of the fixed-combination tablet 3 times daily in patients who experience intolerable effects, but attempt to titrate dosage up once adverse effects subside. Peripheral venous resistance is decreased via a selective action on venous capacitance vessels and results in venous pooling of blood and decreased venous return to the heart. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Typically applied to trunk. Copyright 2023 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Imdur may interact with sildenafil, other vasodilators, alcohol, calcium channel blockers, and organic nitrates. Controlled trials with other formulations of nitroglycerin have demonstrated that if plasma levels are maintained continuously, all anti-anginal efficacy is lost within 24 hours. Monitor Closely (1)lenacapavir will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. and formulary information changes. Use Caution/Monitor. An interdosing interval sufficient to avoid tolerance to Dilatrate-SR extended-release capsules is not known, but it must exceed 18 hours. The observed clearance rates (close to 1 L/kg/min) greatly exceed hepatic blood flow; known sites of extrahepatic metabolism include red blood cells and vascular walls. Readily absorbed from the GI tract; does not undergo first-pass hepatic metabolism. Initially, isosorbide dinitrate conventional tablets (e.g., Isordil Titradose) 520 mg administered 23 times daily, followed by maintenance dosage of 1040 mg administered 23 times daily (some patients may require higher dosages). Use Caution/Monitor. amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. If not feasible, avoid use of abametapir. Use Caution/Monitor. No more than 3 doses in a 15- to 30-minute period. (See Cautions.). Because controlled, long-term trials of nitroglycerin ointment have not been reported, it is not known how the efficacy of nitroglycerin ointment may vary during extended therapy. Always ask your health care professional for complete information about this product and your specific health needs. The Vasodilator-Heart Failure Trials I and II. Coverage of an area approximately the size of the dose-measuring applicator (3 1/2" by 2 1/4") should be sufficient to obtain the desired clinical effects. Make sure laboratory personnel and all your doctors know you use this drug. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Conversion table Original isosorbide prescription: Convert to: 10 mg twice a day at 8am and 4pm 20 mg twice a day at 8am and 4pm Monitor Closely (1)lorlatinib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. informational and educational purposes only. Nitrates in the management of acute coronary syndrome. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others.
